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. 2021 Oct 19;11:747950. doi: 10.3389/fonc.2021.747950

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Copyright © 2021 Zhang, Hu, Han, Wang, Ma, Ye, Yuan, Cao, Zhang, Shi, Chen, Wang, Xu, Cheng, Tian, Wang and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A typical case had the combination therapy and underwent subsequent surgery (case no. 6). (A) Radiology of case no. 6 before treatment: T for tumor 1 and yellow arrow pointing tumor 2. (B) Radiology of case no. 6 after treatment: T for tumor 1 and yellow arrow pointing tumor 2. (C) Three-dimensional reconstruction and surgical plan of case no. 6 after the combination therapy. (D) Surgical photo of the margin (P for pedicle, RHV for right hepatic vein, and UFV for umbilical fissure vein). (E) Reexamination of the liver 6 months after the surgery: No tumor or relapse. (F) Pathology of tumor: moderately differentiated hepatocellular carcinoma (HCC) is focally distributed with extensive necrosis and several inflammatory cells (×100); viable tumor cell rate, 2.5%.