Table 2.
Results of genome-wide association study (GWAS) for logp2PSA in the cohort.
| SNP | CHR | Position a | Loci | Gene | Stage | A/a b | RAF c | Counts (aa/Aa/AA) d | Mean levels (pg/ml) (aa/Aa/AA) d | Beta (SE) | p-value e |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs72725879 | 8 | 128103969 | 8q24.21 | PRNCR1 | 1 | T/C | 0.76 | 51/321/495 | 17.02/29.11/41.78 | 0.18 (0.037) | 2.08 × 10−6 |
| 2 | T/C | 0.76 | 70/393/636 | 22.23/27.10/38.90 | 0.12 (0.030) | 6.24 × 10−5 | |||||
| Combined | T/C | 0.76 | 121/714/1131 | 19.86/27.99/40.18 | 0.14 (0.023) | 2.28 × 10−9 | |||||
| rs13254738 | 8 | 128104343 | 8q24.21 | PRNCR1 | 1 | C/A | 0.75 | 50/341/485 | 15.74/29.38/43.05 | 0.19 (0.037) | 4.22 × 10−7 |
| 2 | C/A | 0.76 | 73/403/648 | 27.16/25.94/38.82 | 0.10 (0.029) | 3.90 × 10−4 | |||||
| Combined | C/A | 0.76 | 123/744/1133 | 21.78/27.48/40.64 | 0.13 (0.023) | 5.31 × 10−9 |
a
Chromosome position based on human genome build 37.
b
A/a, Risk allele/reference allele.
c
RAF indicates the frequency for risk allele A.
d
aa, indicating homozygous with two reference alleles; Aa, heterozygous; AA, indicating homozygous with two risk alleles.
e
P-value was based on multivariate linear regression analysis, adjusted for age and eigen.