Table 3.
Association analysis between logp2PSA and prostate cancer (PCa) risk-associated variants reported by previous genome-wide association study (GWAS) within the region 8q24.21.
| SNP | LD cluster a | CHR | BP b | Status | MA | N | Beta (SE) c | p-value c | PCa risk-associated SNPs identified by previous GWAS d | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RA | OR | p-GWAS | PMID | |||||||||
| rs12543663 | Block 1 | 8 | 127,924,659 | Genotyped | C | 1,919 | −0.056 (0.043) | 0.20 | C | 1.12 | 2.60 × 10−38 | 29892016 |
| rs10086908 | Block 1 | 8 | 128,011,937 | Genotyped | C | 1,919 | −0.083 (0.027) | 1.82 × 10−3 | T | 1.13 | 1.80 × 10−47 | 29892016 |
| rs1016343 | Block 2 | 8 | 128,093,297 | Genotyped | T | 1,919 | 0.096 (0.02) | 3.04 × 10−6 | T | 1.25 | 5.40 × 10−21 | 26034056 |
| rs13252298 | Block 2 | 8 | 128,095,156 | Genotyped | G | 1,919 | −0.11 (0.022) | 6.50 × 10−7 | A | 1.11 | 4.10 × 10−10 | 19767752 |
| rs72725879 | Block 2 | 8 | 128,103,969 | Imputed | C | 1,886 | −0.14 (0.023) | 2.28 × 10−9 | NA | NA | NA | NA |
| rs6983561 | Block 2 | 8 | 128,106,880 | Genotyped | C | 1,919 | 0.11 (0.022) | 3.65 × 10−7 | C | 1.13 | 4.60 × 10−19 | 26034056 |
| rs16901979 | Block 2 | 8 | 128,124,916 | Imputed | A | 1,919 | 0.11 (0.022) | 1.58 × 10−6 | A | 1.56 | 1.40 × 10−105 | 29892016 |
| rs16902094 | Block 2 | 8 | 128,320,346 | Genotyped | G | 1,919 | 0.0054 (0.023) | 0.81 | G | 1.20 | 6.20 × 10−15 | 19767754 |
| rs445114 | Block 2 | 8 | 12,832,3181 | Genotyped | C | 1,919 | 0.0015 (0.020) | 0.94 | T | 1.19 | 4.70 × 10−10 | 19767754 |
| rs620861 | Block 3 | 8 | 128,335,673 | Genotyped | A | 1,919 | 0.0093 (0.020) | 0.65 | G | 1.15 | 4.90 × 10−63 | 29892016 |
| rs16902104 | Block 3 | 8 | 128,340,908 | Imputed | T | 1,827 | 0.0041 (0.023) | 0.86 | T | 1.21 | 5.30 × 10−10 | 26034056 |
| rs6983267 | Block 4 | 8 | 128,413,305 | Genotyped | G | 1,919 | 0.045 (0.020) | 0.026 | G | 1.22 | 2.80 × 10−141 | 29892016 |
| rs1447295 | Block 5 | 8 | 128,485,038 | Genotyped | A | 1,919 | 0.094 (0.027) | 5.38 × 10−4 | A | 1.41 | 1.20 × 10−179 | 29892016 |
| rs11986220 | Block 5 | 8 | 128,531,689 | Genotyped | A | 1,896 | 0.12 (0.027) | 1.13 × 10−5 | A | 1.56 | 2.30 × 10−40 | 26034056 |
| rs7837688 | Block 5 | 8 | 128,539,360 | Genotyped | T | 1,919 | 0.13 (0.027) | 4.25 × 10−6 | T | 1.43 | 1.85 × 10−14 | 17401363 |
LD, linkage disequilibrium; CHR, chromosome; BP, base pair; MA, minor allele; RA, risk allele; OR, odds ratio; NA, not applicable.
a
LD block information referring to the report by Olama et al. (28).
b
Chromosome position based on human genome build 37.
c
P-value, beta and standard error (SE) were based on multivariate linear regression analysis, adjusted for age.
d
The RA, OR, and p-GWAS were from previously reported GWAS.