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The role of non-coding RNAs in the etiology of leprosy. Several ncRNAs are found to be instrumental in the induction or inhibition of the host effector killing functions against Mycobacterium leprae. More research needed to identify 1- host ncRNAs that regulate the parasite entry within the host, its engulfment within phagosome and the fusion between phagosome and lysosomes; 2- the role of M. leprae-derived ncRNAs on the outcome of mycobacterium-macrophage interaction.
