Table 1.
Non-coding RNAs in the etiology and control of tuberculosis.
| Role in tuberculosis | Non-coding RNA | Action | Reference |
|---|---|---|---|
| Etiology | miR-26-5p | Inhibition of innate immunity | (18) |
| miR-132-3p | (18) | ||
| miR-155-5p | (18, 19) | ||
| miR-29-3p | (18) | ||
| miR-21-5p | Suppression of inflammation | (18) | |
| miR-27b-3p | (18) | ||
| miR-99b-5p | (18) | ||
| miR-125-5p | (18) | ||
| miR-146a-5p | (18) | ||
| miR-223-3p | (18) | ||
| let-7f | (18) | ||
| miR-20b-5p | (18) | ||
| miR-142-3p | (18) | ||
| miR-33 locus | Inhibition of phagosome maturation and autophagy | (18) | |
| miR-27a-5p | (18, 20) | ||
| miR-144-5p | (18) | ||
| miR-889-5p | (18) | ||
| miR-155-5p | Apoptosis inhibition | (18) | |
| miR--582-5p | (18) | ||
| Diagnosis | miR-769-5p | Downregulation in TB patients | (8) |
| miR-320a | |||
| miR-22-3p | |||
| miR-423-5p | Upregulation in TB patients | (21) | |
| miR-17-5p | |||
| miR-20b-5p | |||
| lncRNA LOC152742 | (22) | ||
| Therapeutic targets | lncRNAs NEAT1 | Downregulation during drug treatment, association with disease improvement | (23) |
| lncRNAs NEAT2 | (23) | ||
| lnrRNA 152742 | (22) | ||
| lncRNAENST00000429730.1 | Downregulation during drug treatment, associated with complete inactivation of tuberculosis lesions from sputum negative patients | (24) | |
| lncRNA MSTRG.93125.4 | (24) |