FIG. 5.

Alignment of p270 and SWI1. p270 and SWI1 have an overall similarity of structure, in that they both contain ARID regions and they both have multiple LXXLL motifs (which are implicated in binding to nuclear hormone receptors), as well as Q-rich regions, which are often associated with transactivation regions. SWI1 has an unusual asparagine- and threonine-rich stretch near the N terminus; we do not yet know if this feature also occurs in p270. Other than these common features, p270 and SWI1 do not show direct sequence homology.