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. 2021 Nov 1;11:21394. doi: 10.1038/s41598-021-00884-5

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Design of biomimetic CB-SAHs for weight management. Taking inspiration from basic compositional and structural properties of raw vegetables while in transit through the GI tract, we designed novel CB-SAHs based on crosslinked carboxymethylcellulose sodium salt (CMC). The CB-SAHs are orally administered in capsules, hydrate in the stomach, mix up with the ingested food, and move along the small intestine without being absorbed. Once in the colon (not depicted in the scheme), they undergo partial degradation to return the absorbed water to the body, while the cellulosic material is excreted with the feces.