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. 2021 Nov 1;11:21408. doi: 10.1038/s41598-021-00969-1

Table 1.

Baseline characteristics of enrolled patients after endoscopic submucosal dissection with curative resection.

Total
(n = 698)
No recurrence
(n = 647)
Recurrence
(n = 51)
P-value*
Age, mean ± SD, years 61.8 ± 10.0 61.5 ± 10.1 66.0 ± 8.7  < 0.01
Sex, n (%) 0.01
Male 498 (71.3) 454 (70.2) 44 (86.3)
Female 200 (28.7) 193 (29.8) 7 (13.7)
Location, n (%) 0.60
Upper third 28 (4.0) 27 (4.2) 1 (2.0)
Middle third 256 (36.7) 239 (36.9) 17 (33.3)
Lower third 414 (59.3) 381 (58.9) 33 (64.7)
Lesion diameter
Mean ± SD, mm 17.9 ± 8.3 17.8 ± 8.3 19.4 ± 8.5 0.17
 ≤ 10 mm, n (%) 150 (21.5) 143 (22.1) 7 (13.7)
11–20 mm, n (%) 365 (52.3) 338 (52.2) 27 (52.9)
21–30 mm, n (%) 137 (19.6) 125 (19.3) 12 (23.5)
 > 30 mm, n (%) 46 (6.6) 41 (6.3) 5 (9.8)
Gross morphology type, n (%) 0.20
Elevated/flat 669 (95.8) 618 (9.5) 51 (100.0)
Depressed 29 (4.2) 29 (4.5)
Number of lesion, n (%)
Single 634 (90.8) 592 (91.5) 42 (82.4) 0.04**
Multiple 64 (9.2) 55 (8.5) 9 (17.6)
Atrophy gastritis, n (%) 500 (71.6) 454 (70.2) 46 (90.2)  < 0.01
Antrum 180 (36.0) 171 (37.7) 9 (19.6)
Expanded to the lesser curvature of the body 269 (53.8) 240 (52.9) 29 (63.0)
Entire stomach 51 (10.2) 43 (9.4) 8 (17.4)
Intestinal metaplasia, n (%) 534 (76.5) 489 (75.6) 45 (88.2) 0.04
Helicobacter pylori infection, n (%) 0.95
Current 203 (29.1) 188 (29.1) 15 (29.4)
Previous (including eradicated) 167 (23.9) 154 (23.8) 13 (25.5)
None 328 (47.0) 301 (46.5) 23 (45.1)
Specimen area − lesion areaa, mean ± SD, mm2 2.4 ± 1.4 2.4 ± 1.3 2.7 ± 1.6 0.19
Total procedure time 50.8 ± 32.7 51.2 ± 33.3 46.2 ± 24.6 0.30
Fibrosis during ESD, n (%) 131 (18.8) 127 (19.6) 4 (7.8) 0.04
Presence of ulceration at 1st follow-up, n (%) 17 (2.4) 16 (2.5) 1 (2.0) 0.82
Scar morphology at 1st follow-upb, n (%)  < 0.001
Flat scar 642 (92.0) 602 (93.0) 40 (78.4)
Protruded scar 56 (8.0) 45 (7.0) 11 (21.6)
Discrepancy, n (%) 0.85
Downgrade and concordant 647 (92.8) 600 (92.9) 47 (92.2)
Upgrade 50 (7.2) 46 (7.1) 4 (7.8)

ESD, endoscopic submucosal dissection; n, number; NA, not applicable; SD, standard deviation.

*Non-recurrence vs. recurrence.

**Fisher’s exact test was applied.

a(Area of the specimen − area of the lesion)/1000.

bIf ulceration was observed at the first follow-up, scar morphology was evaluated according to endoscopy at the 6-month follow-up.