Impact of vitamin E acetate (VEA) on inhaled particle count
(A) Real-time particle count (per cm3) as a function of time for four particle size distributions (300 nm–1 μm, 1 μm–2.5 μm, 2.5 μm–4 μm, and 4 μm–10 μm) during 9 cycles of the vaping session is illustrated. The data were generated from representative e-liquid containing VEA at 5% (v/v) concentration in 50/50 propylene glycol/vegetable glycerin (PG/VG).
(B) Distribution profiles of the total particle counts per cm3 over each inter-puff interval for each size fraction (300 nm–1 μm, 1 μm–2.5 μm, 2.5 μm–4 μm, and 4 μm–10 μm) in the absence or presence of increasing doses of VEA (v/v at 0%, 1.25%, 2.5%, and 5%) are plotted. Kruskal-Wallis test demonstrated statistical significance (p < 0.0001), and post-hoc analysis (Dunn’s multiple comparison test) showed statistically significant differences between all data sets except 1.25% and 2.5% for all particle size distributions. Error bars indicate mean and 95% confidence intervals for each data set.