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. 2021 Nov 1;11:21348. doi: 10.1038/s41598-021-00870-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Assessment of VLCFA-lipids in FTD serum. Quantitative discovery lipidomics LC/MS detected five VLCFA-TG species in the human serum, of which one was significantly decreased in FTD (n = 40) compared to controls (n = 22). Relative abundance of lipids was obtained from LC/MS peak areas normalized to internal standards. Multivariate analysis (general liner model), co-varying for age and sex, was used to determine significance between the two groups. Data represent mean and SE as error bars, *P < 0.05.