TABLE 1.

Optimization of the reaction condition and synthesis of donepezil hybrids using chlorotrimethylsilane as reagent.

Entry	Alcohol	Solvent	Temp. (°C)	Time (days)	Alcohol (eq.)	CTMS (eq.)	Yield (%) a
1	1	DCM	r.t.	2	10	2.5	30
2	1	THF	r.t.	6	10	2.5	42
3	1	THF	40°C	6	10	2.5	65
4	1	THF	40°C	6	5	3.5	40
5	1	THF	Reflux	2	3.4	7.8	27
6	1	THF	Reflux	3	3.4	7.8	36
7	2	THF	40°C	6	10	2.5	15
8	3	THF	40°C	6	10	2.5	50
9	4	THF	40°C	6	10	2.5	55

^aIsolated yields.