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. 2021 Nov 1;12:6276. doi: 10.1038/s41467-021-26502-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Heatmap shows all differentially (FDR <0.05 and β-value>0.1) methylated CpGs by subtype. b Graph shows the number of differentially) hypomethylated and hypermethylated CpGs by TNBC subtype. c Barplots show the percentage of hypomethylated (blue) and hypermethylated (yellow) CpGs within each chromosome by TNBC subtype. d Pie charts show the distribution of differentially methylated CpG sites in each subtype by genomic location. e Starburst plots show gene expression and DNA methylation <3kb from promoter regions of corresponding genes. Significantly (FDR <0.05) hypo- and hyper-methylated promoter regions are colored in blue and yellow respectively, with genes of interest labeled in the plot. f Gene set enrichment analysis of genes negatively correlated with hypomethylated (blue) or hypermethylated (yellow) promoter methylation probes.