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. 2021 Nov 1;11:21372. doi: 10.1038/s41598-021-00625-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of run characteristics and kinetic, temporal and spatial parameters between C57BL/6N and DBA/2 mice at P42. (a) DBA/2 mice showed a significant increase in the average speed and cadence, but no difference in the number of steps compared to C57BL/6N mice. (b,c) DBA/2 mice showed an increase in the body speed (b) and swing speed (c) of all paws compared to C57BL/6N mice. (d) DBA/2 mice showed a significant decrease in the stand time of LF and RF paws. (e) DBA/2 mice showed a significant decrease in the swing time of all paws. (f) DBA/2 mice showed a significant decrease in the step cycle of LF, RF and RH paws. (g) DBA/2 mice showed a significant decrease in the maximum contact at (%) of both LF and RF paws compared to C57BL/6N mice. (h,i) DBA/2 mice showed an increase in the print area of all paws (h) and a decrease in the maximum intensity of the RH paw compared to C57BL/6N mice. (i). Two-way ANOVA followed by Bonferroni post hoc test, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. A red rectangle indicates a significant difference between sexes within a strain (see Supplementary Table S1). Error bars indicate the standard error of the mean (SEM). RF right front, LF left front, RH right hind, LH left hind.