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. 2021 Nov 1;11:21354. doi: 10.1038/s41598-021-98642-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Glycolysis and PPP metabolite levels per treatment groups and their floating populations. Metabolite levels were QC-normalized and mapped to glycolysis and pentose phosphate pathway to show the metabolic reactions in the cell. A single arrow denotes direct conversion in a single reaction and a segmented arrow denotes conversion with multiple step reactions. Rate limiting reactions are marked with #. Samples are color-coded and samples with floating cells are hatched. All graphs show mean relative normalized metabolite peak areas ± standard error (SEM). Please note y-axis scales are different between the plots. *p < 0.05, **p < 0.01 versus CTRL unless otherwise indicated.