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. 2021 Nov 1;11:21361. doi: 10.1038/s41598-021-00898-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Perceptual quality comparison, on the DeepLesion test images $2 \times$ and $4 \times$ super-resolved held out for performance evaluation, obtained by the investigated SR methods. The PSNR and SSIM values are shown at the bottom of each super-resolved image. In the case of $4 \times$ SR, GAN-CIRCLE^x denotes the sequential application of two GAN-CIRCLE instances at $2 \times$ SR.