Table 2.
Cerebrospinal fluid characteristics of patients with varicella zoster virus infection and neuroborreliosis.
| VZV infection | Neuroborreliosis | p-value a | |
|---|---|---|---|
| RBC count (cells/μL), median (IQR) | 2 (0–21) | 4 (0–7) | 0.719 |
| WBC count (cells/μL), median (IQR) | 99 (18–274) | 154 (105–216) | 0.037 |
| CSF/serum glucose ratio, median (IQR) | 0.55 (0.48–0.67) | 0.53 (0.44–0.65) | 0.227 |
| CSF total protein (mg/dL), median (IQR) | 67 (46–102) | 102 (46–179) | 0.132 |
| Qalb, median (IQR) | 9.44 (6.79–16.22) | 14.79 (6.8–28.83) | 0.183 |
| IgG index, median (IQR) | 0.58 (0.51–0.66) | 0.79 (0.62–1.01) | <0.001* |
| Intrathecal IgG synthesis (%), median (IQR)1 | 0 (0–0) | 2.02 (0–25.56) | <0.001* |
| Intrathecal IgA synthesis (%), median (IQR) 1 | 0 (0–0) | 0 (0–6.39) | 0.059 |
| Intrathecal IgM synthesis (%), median (IQR) 2 | 0 (0–0) | 42.54 (0–66.4) | <0.001* |
| VZV antibody index, median (IQR)3 | 2.1 (0.6–3.1) | na | na |
| Borrelia antibody index, median (IQR) | na | 23.6 (7.5–43.8) | na |
Data from: 1 90 cases, 2 85 cases, 3 31 cases (18 cases>1.5). CSF WBC and RBC were counted within the Fuchs-Rosenthal chamber (volume of 3.2 μL). Counts are reported as “cells/μL” (correction for a standard volume of 1 μL was achieved by dividing by 3.2). CSF, cerebrospinal fluid; IQR, interquartile range; n, number; na, not applicable; PCR, polymerase chain reaction; RBC, red blood cell; WBC, white blood cell; Qalb, CSF/serum albumin quotient; VZV, varicella zoster virus.
a
calculated by Mann-Whitney U test, uncorrected p-values are shown, after Bonferroni correction still significant at a level of 0.05.