Table 5.
Laboratory values, intervals of assessment and reference values.
| Parameter | Assessment interval | Vial | Unit | reference value |
|---|---|---|---|---|
| Blood count | ||||
| Erythrocytes | quarterly | EDTA | 10\S\12/l | 4.00 – 5.20 |
| Hb | quarterly | EDTA | g/dl | 12.0 – 16.0 |
| Leukocytes | quarterly | EDTA | 10\S\9/l | 3.9 – 10.2 |
| Thrombocytes | quarterly | EDTA | 10\S\9/l | 140 – 400 |
| Differential leukocyte count | ||||
| Neutrophils rel. | quarterly | EDTA | % | 42.0 – 77.0 |
| Neutrophils abs. | quarterly | EDTA | 10\S\9/l | 1.5 – 7.7 |
| Lymphocytes | quarterly | EDTA | % | 25.0 – 45.0 |
| Monocytes | quarterly | EDTA | % | 2.0 – 10.0 |
| Eosinophils | quarterly | EDTA | % | 0.0 – 5.0 |
| Basophils | quarterly | EDTA | % | 0.0 – 1.0 |
| Biochemical parameters | ||||
| Sodium | quarterly | Li-Heparin-Plasma | mmol/l | 135 – 145 |
| Potassium | quarterly | Li-Heparin-Plasma | mmol/l | 3.5 – 5.1 |
| Calcium | quarterly | Li-Heparin-Plasma | mmol/l | 2.2 – 2.6 |
| Magnesium | quarterly | Li-Heparin-Plasma | mmol/l | 0.66 – 1.07 |
| Iron | quarterly | Li-Heparin-Plasma | µg/dl | 33 – 193 |
| Creatinin | quarterly | Li-Heparin-Plasma | mg/dl | 0.50 – 0.90 |
| Urea | quarterly | Li-Heparin-Plasma | mg/dl | 17 – 48 |
| Uric acid | quarterly | Li-Heparin-Plasma | mg/dl | 2.5 – 5.7 |
| Glucose | quarterly | Li-Heparin-Plasma | mg/dl | 60 – 100 |
| Protein | quarterly | Serum | g/l | 66 – 87 |
| Albumin | quarterly | Serum | g/l | 35 – 52 |
| Cholesterol | quarterly | Li-Heparin-Plasma | mg/dl | <200 |
| Triglycerides | quarterly | Li-Heparin-Plasma | mg/dl | <150 |
| CK | quarterly | Li-Heparin-Plasma | U/l | 0 – 170 |
| ASAT | quarterly | Li-Heparin-Plasma | U/l | 0 – 35 |
| ALAT | quarterly | Li-Heparin-Plasma | U/l | 0 – 35 |
| gamma-GT | quarterly | Li-Heparin-Plasma | U/l | <40 |
| Alkaline phosphatase | quarterly | Li-Heparin-Plasma | U/l | 35 – 104 |
| Bilirubin | quarterly | Li-Heparin-Plasma | mg/dl | <1.2 |
| Lipase | quarterly | Li-Heparin-Plasma | U/l | 13 – 60 |
| LDH | quarterly | Li-Heparin-Plasma | U/l | 0 – 262 |
| CRP | quarterly | Li-Heparin-Plasma | mg/l | 0.0 – 5.0 |
| HbA1c | quarterly | EDTA | % | <6.0 |
| LDL-Cholesterol | quarterly | Li-Heparin-Plasma | mg/dl | <130 |
| HDL-Cholesterol | quarterly | Li-Heparin-Plasma | mg/dl | 45 – 65 |
| VLDL-Cholesterol | quarterly | Li-Heparin-Plasma | mg/dl | <35 |
| Interleukin-6 | quarterly | Li-Heparin-Plasma | pg/ml | <7 |
| Selenium | quarterly | Serum | µg/l | 50 – 120 (67) |
| Vitamin D-25-OH | quarterly | Serum | ng/ml | 30 – 100 (68) |
| Hormones | ||||
| TSH | quarterly | Li-Heparin-Plasma | µIU/ml | 0.27 – 4,2 |
| fT3 | quarterly | Li-Heparin-Plasma | pg/ml | 2.0 – 4.4 |
| fT4 | quarterly | Li-Heparin-Plasma | ng/dl | 0.93 – 1.7 |
| Cortisol | quarterly | Serum | µg/dl | 4.82 – 19.5* |
| Insulin | quarterly | Serum | µIU/ml | <29.1 |
| ß-hCG | quarterly | Serum | mIU/ml | <1.0 |
| Tumor marker | ||||
| CA 15-3 | optional | Serum | U/ml | <26.2 |
*Reference values for Cortisol vary depending on the time of blood collection. As in the BEGYN study, samples were routinely taken in the morning these standard values were used.