Table 1.
Nanozyme Classification and Applications.
| Nanozyme system | Mimetic activities | Applications | References |
|---|---|---|---|
| Carbon-Based | |||
| SWNTs | POD | Drug delivery; Human SNP DNA detection | (11, 24) |
| GO | POD | Tumor visual detection | (63) |
| GO-COOH | GOx; POD | Glucose detection | (15) |
| GFH | POD | Tumor detection | (17) |
| C-Dots | POD | Glucose detection | (22) |
| HFn-N-CNMs-3 | POD; OXD (acidic pH values) | Tumor catalytic therapy | (25) |
| SOD; CAT (neutral pH values) | Anti-oxidant therapy | (25) | |
| Metal-Based | |||
| Au NPs | GOx | Self-limiting nanomedicine; Biomedical probe | (14, 111) |
| EMSN-AuNPs | GOx; POD | Self-activated cascade catalysis | (28) |
| AuNCs | POD | Tumor detection | (64) |
| BSA-AuNCs | POD | A dual fluorometric and colorimetric sensor for dopamine | (29) |
| Au/SiO2 nanocomposites | POD | Realizing high-temperature catalytic reactions | (30) |
| AuNCs-NH2 | CAT | Enhancing PDT efficiency | (83) |
| Carbon-gold hybrid nanoprobes | CAT | Real-time imaging, enhancing PTT and PDT efficiency | (111) |
| Au2Pt-PEG-Ce6 | CAT; POD | Synergistic chemotherapy and phototherapy | (112) |
| Pt NPs | CAT | Enhancing RT efficiency | (113) |
| Pt NPs/GO | POD | Tumor detection | (62) |
| PtPB | CAT; SOD | Enhancing PTT efficiency | (89) |
| Pt-MOFs hybrid system | CAT | Enhancing PDT efficiency | (81) |
| Pt-Carbon nanozyme | CAT | Enhancing PDT and PTT efficiency | (84) |
| P@Pt@P−Au−FA | CAT; GOx | Synergistic starving-like therapy and PDT | (87) |
| Pd@Pt-T790 | CAT | Enhancing SDT efficiency; anti-bacterial infection | (92, 93) |
| CDP@HP-T | CAT | Synergistic chemotherapy and SDT | (94) |
| AFeNPs | Fenton reaction | Enhancing MRI contrast and chemotherapy effects | (105) |
| Fe@BC | POD | Anti-bacterial infection | (27) |
| Rh-PEG NDs | CAT | Anti-inflammation and anti-tumor | (46) |
| OxgeMCC-r SAE | CAT | Enhancing PDT efficiency | (114) |
| IMSN-PEG-TI | POD; CAT | Anti-tumor | (58) |
| Metal Oxide-Based | |||
| Fe3O4 MNPs/IONPs | POD (acidic pH values) | Detection of organophosphorus pesticide and nerve agent | (3, 16, 39) |
| CAT (neutral pH values) | Anti-oxidant | (39) | |
| PtFe@Fe3O4 | POD; CAT | Synergistic tumor catalytic therapy and PTT | (109) |
| DMSN-Au-Fe3O4 NPs | POD; GOx | Anti-tumor | (41) |
| Nanoceria | SOD (neutral pH values) | Against radiation damage, oxidative stress and inflammation | (9, 10, 38) |
| Fluorogenic detection of cancer | |||
| Folate-conjugated Nanoceria | OXD (acidic pH values) | Cancer detection | (9) |
| PEG-CNPS | SOD | Radical scavenger with tunable redox chemistry | (36) |
| A-MnO2 NPs | CAT | Modulating TME and enhancing RT responses | (102) |
| MnO NPs | SOD | Enhancing MRI contrast | (74) |
| Au@MnO2-PEG | CAT | Enhanced RT via improving the tumor oxygenation | (104) |
| Mn3O4 NPs | SOD; CAT; GPx | Anti-inflammation | (76) |
| MnO2@PtCo | OXD; CAT | Anti-tumor | (75) |
| rMGB | CAT | Enhancing starvation and PDT against hypoxic tumor | (110) |
| Ru@CeO2-RBT/Res-DPEG | CAT | Enhancing dual chemotherapy combined with PTT | (108) |
| PEG-TiO1+x NRs | POD | Enhancing dual chemotherapy combined with SDT | (96) |
| Metal Chalcogenide | |||
| CuS-GNSs | POD; GOx | Detection of H2O2 and human serum glucose level | (44) |
| Hollow Pt-CuS Janus | POD | Synergistic PTT and SDT | (47) |
| DMHSs-FeS2/SiO2 | POD | Detection of H2O2 and GSH for anti-tumor | (50) |
| SVs-Fe3S4 | POD | Detection of human serum glucose level | (51) |
| FeS2 | OXD; POD | Anti-tumor | (35) |
| PEG/Ce-Bi@DMSN | POD; CAT | Synergistic tumor catalytic therapy and PTT | (88) |