Figure 6.

Bacterial association networks and differences with age: Bacterial association networks and differences with age: Markov Clustering Algorithm (MCL) evaluates correlations of vector abundance of bacterial species within each group, thereby generating a cluster map by using correlation scores as distance. Figure shows that microbiome of young adult animals group into a single large super-cluster at microbial homeostasis (A). However, with age, major constraints have been introduced into the network structure with the emergence of satellite clusters and scattering of the super cluster (B). Cluster identities are listed in Supplementary Figure 4 . Different colors signify different MCL minor clusters within the microbiome. The data used is species-level identified list, and the rendering for MCL includes only those with Pearson’s r > 0.85 and unidentifiable feature-level sequences were not included for this analysis.