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. 2021 Oct 6;24(11):103233. doi: 10.1016/j.isci.2021.103233

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The identification of HSC1 endothelial-chimeric stellate cell subpopulation

(A) Volcano plot of differentially expressed genes in endothelial-chimeric stellate cells HSC1 compared to HSC2. DEGs were colored based on enriched pathways.

(B) Expression profile of stellate cell marker Lum and endothelial cell marker Ptprb in endothelial, stellate, and endothelial-chimeric stellate cells.

(C) Representative Ptprb and Lum double RNA–ISH images to show the distribution of HSC1 and HSC2 in healthy liver. Arrows indicate double stained cells. Images are same magnification. Scale bar indicates 20 um. PP: periportal; PV: perivenous.

(D) Representative Ptprb and Lum double RNA–ISH images to show the distribution of HSC1 and HSC2 in NASH liver. Bottom panel showed the clustered HSC1 double-positive cells. Arrows indicate double stained cells. Images are same magnification. Scale bar indicates 20 um.