Figure 3.

Hoil-1l^{nzf∗/nzf∗} mice show reduced responses to TNF-induced shock

(A) Temperature of Hoil-1l^+/+ (n = 5) and Hoil-1l^{nzf∗/nzf∗} (n = 4) upon intravenous TNF injection (450 μg/kg) monitored over time.

(B–D) IL-6 (B), IL-12 (C), and G-CSF (D) levels in the serum of unstimulated (UNST) and TNF-injected mice. After 12 h of TNF injection, serum levels of indicted cytokines were measured by ELISA. UNST: Hoil-1l^+/+ (n = 6), Hoil-1l^{nzf∗/nzf∗} (n = 6), TNF: Hoil-1l^+/+ (n = 5), Hoil-1l^{nzf∗/nzf∗} (n = 4). Data are represented as mean ± SD. ANOVA, ∗p value ≤0.05, ∗∗∗p value ≤0.001.