Figure 3.

Plasma and breast milk ADCC relative to neutralization and immunoglobulin isotypes

(A and B) ADCC_AUC correlation with Neut_AUC among infants (A) and mothers (B).

(C and D) ADCC from breast milk (BM)-isolated IgG relative to breast milk supernatant (BMS).

(E and F) IgG to IgA ratio among infants (E), and IgG to IgA ratio among infants relative to infant ADCC_AUC (F).

The red and black dots indicate TMs/HEI and NTMs/HEU, respectively, and colors in (E) signify matched pairs. In (E), bars show mean and standard error. Correlations were assessed using Spearman’s statistic. Lines indicate linear regression fit with a 95% confidence interval. Group comparisons were done using matched pairs Wilcoxon rank-sum (D) or Welch’s t test (E). ∗∗p ≤ 0.01, ∗∗∗∗p ≤ 0.0001. All values represent mean values from a minimum of 2 replicates.