Table: Amino acids used in each coupling step for the synthesis of 3

Coupling step	Reagent	mmol	Equivalent	MW (g/mol)	Amount (g)
	H-Pen(Trt)-2-Cl−Trt-resin (loading 0.56 mmol/g)	4.05			7.25
1	Fmoc-saccharo-Glu-OH	8.1	2	613	5.0
2	Fmoc-Glu(Ot-Bu)-OH	8.1	2	425	3.4
3	Fmoc-saccharo-Glu-OH	6.5	1.6	613	3.9
4	Fmoc-Glu(Ot-Bu)-OH	8.1	2	425	3.4
5	Fmoc-saccharo-Glu-OH	6.5	1.6	613	3.9
6	Fmoc-Glu-Ot-Bu	8.1	2	425	3.4
7	N10-TFA-Pteroic Acid	7.1	1.8	408	2.9