Table 1.
Isolates exhibiting aztreonam/avibactam MIC results ≥4 mg/L selected for further characterization of resistance mechanisms
| Collection number | Site code | Country | City | Organism | MIC (mg/L) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ATM | ATM/AVI | ATM/CLA | CAZ | CAZ/AVI | CAZ/CLA | COZ/TZB | CRO | FEP | SAM | TZP | MEM | IPM | ETP | |||||
| 1108470 | 68 | Turkey | Ankara | E. coli | >64 | 8 | 32 | >128 | 2 | >128 | >16 | >8 | >256 | >64 | >128 | 0.03 | 0.25 | 0.12 |
| 1108523 | 68 | Turkey | Ankara | E. coli | 32 | 8 | 32 | >128 | 2 | >128 | >16 | >8 | 32 | >64 | >128 | 0.03 | 0.25 | 0.12 |
| 1108694 | 68 | Turkey | Ankara | E. coli | 64 | 8 | 64 | >128 | 2 | >128 | >16 | >8 | 8 | 64 | 128 | 0.06 | 0.5 | 0.12 |
| 1114251 | 69 | Turkey | Istanbul | E. coli | >64 | 16 | 32 | >128 | 8 | >128 | >16 | >8 | >256 | >64 | >128 | 0.06 | 1 | 0.5 |
| 1114255 | 69 | Turkey | Istanbul | E. coli | 64 | 8 | 64 | >128 | 8 | >128 | >16 | >8 | 128 | >64 | >128 | 1 | 4 | >2 |
| 1118669 | 606 | Korea | Kangwondo | E. coli | >64 | 4 | 32 | >128 | >32 | >128 | >16 | >8 | >256 | >64 | >128 | 32 | >8 | >2 |
| 1116284 | 603 | Thailand | Bangkok | E. coli | >64 | 8 | 16 | >128 | 4 | 16 | >16 | >8 | >32 | 64 | >128 | 0.03 | ≤0.12 | 0.5 |
| 1128667 | 380 | France | Rennes Cedex | E. coli | >64 | 4 | 8 | >128 | 1 | 8 | >16 | >8 | >256 | 64 | 64 | 0.03 | ≤0.12 | 0.25 |
| 1130864 | 86 | Italy | Rome | E. coli | >64 | 8 | 16 | >128 | 8 | 16 | >16 | >8 | >256 | >64 | >128 | 0.12 | 0.25 | 2 |
| 1116957 | 263 | Australia | Sydney | E. coli | 16 | 8 | 32 | >128 | 2 | >128 | >16 | >8 | 64 | >64 | >128 | 0.03 | 0.25 | 0.25 |
| 1126350 | 283 | Vietnam | Hanoi | E. coli | >64 | 16 | 64 | >128 | 4 | >128 | >16 | >8 | >256 | >64 | >128 | 0.12 | 0.25 | >2 |
| 1122568 | 40 | Argentina | Buenos Aires | K. pneumoniae | >64 | 8 | 0.25 | >128 | 16 | 1 | >16 | >8 | 32 | >64 | >128 | 1 | 0.5 | >2 |
| 1125511 | 215 | Taiwan | Taipei | K. pneumoniae | >64 | 8 | >64 | >128 | 4 | >128 | >16 | >8 | 8 | >64 | >128 | 0.5 | 1 | >2 |
| 1116221 | 603 | Thailand | Bangkok | K. pneumoniae | >64 | >16 | >64 | >128 | 16 | >128 | >16 | >8 | 16 | >64 | >128 | 4 | 4 | >2 |
| 1102685 | 614 | Australia | Melbourne | E. cloacae | 64 | 4 | >64 | >128 | 1 | >128 | >16 | >8 | 32 | 16 | 128 | 0.03 | ≤0.12 | 0.03 |
| 1108008 | 81 | Poland | Warsaw | E. cloacae | 64 | 4 | 64 | >128 | 4 | 128 | >16 | >8 | 128 | >64 | >128 | 2 | 2 | >2 |
| 1118254 | 81 | Poland | Warsaw | E. cloacae | >64 | 16 | >64 | >128 | 2 | >128 | >16 | >8 | 32 | >64 | >128 | 0.12 | 0.5 | 2 |
ATM, aztreonam; ATM/AVI, aztreonam/avibactam (at fixed concentration of 4 mg/L); ATM/CLA, aztreonam/clavulanate (at fixed concentration of 4 mg/L); CAZ, ceftazidime; CAZ/AVI, ceftazidime/avibactam; CAZ/CLA, ceftazidime/clavulanate; COZ/TZB, ceftolozane/tazobactam (at fixed concentration of 4 mg/L); CRO, ceftriaxone; FEP, cefepime; SAM, ampicillin/sulbactam; TZP, piperacillin/tazobactam; MEM, meropenem; IMP, imipenem; ETP, ertapenem.