Figure 2.

Prevalence of CDKN2A and PTEN deletions among different peripheral T-cell lymphoma subtypes. (A) Heatmap showing the prevalence of CDKN2A and PTEN deletions across the main peripheral T-cell lymphoma (PTCL) subtypes. (B) representative fluorescence in situ hybridization (FISH) pictures of PTEN (top) and CDKN2A (bottom) deletions. (C) Frequency table of CDKN2A deletions, mono- and bi-allelic, and co-occurrence with PTEN deletions across PTCL subtypes. All statistical comparisons were performed by Fisher’s exact test. Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) showed a significant enrichment for these three genomic aberrations compared to all the other PTCL histologies (P<0.01). ALCL: anaplastic large cell lymphoma; AITL: angioimmunoblastic T-cell lymphoma neg: negative; pos: positive.