Table 5. Agreement Between Information in the Registry and Information Reported in the Published Trials Across Registries.
| Variable | ClinicalTrials.gov | EudraCT | ISRCTN | Other registriesa | ||||
|---|---|---|---|---|---|---|---|---|
| No./total No. | % (95% CI) | No./total No. | % (95% CI) | No./total No. | % (95% CI) | No./total No. | % (95% CI) | |
| Different primary outcome (n = 25)a | 9/14 | 64 (35-87) | 6/14 | 43 (18-71) | 1/3 | 33 (1-91) | 1/5 | 20 (1-72) |
| Different planned sample size (n = 75)b | 16/46 | 35 (21-50) | 16/40 | 40 (25-57) | 2/5 | 40 (5-85) | 4/8 | 50 (16-84) |
Abbreviations: EudraCT, European Union Drug Regulating Authorities Clinical Trials Database; RCT randomized clinical trial.
a
No publication identified for 6 RCTs, 1 published article did not define primary outcome, and 1 explained different registry entries.
b
No publication identified for 13 RCTs and no planned sample size reported in 16 published articles.