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. 2021 Nov 2;18(12):2588–2608. doi: 10.1038/s41423-021-00784-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Flow plots of the IFN-γ ICS response to the individual peptide pools in transgenic mice. Splenocytes from each primed mouse were harvested 7 days after the last booster and stimulated ex vivo with five different peptide pools according to a single protein, AFP peptides (AFP_158–166, AFP_424–432) as irrelevant controls, or without peptide as negative control, followed by IFN-γ ICS. The data in the left upper quadrant indicate the frequencies of IFN-γ⁺ T cells in the CD3⁺/CD8⁺ cell populations. Control group: N.S and PLGA-NPs; Vaccine A group: PLGA-NPs/peptides vaccines; Vaccine B group: R848/peptides vaccines; Vaccine C group: poly I: C/peptides vaccines