FIG 2.

Male sex is a risk factor for death in a preclinical model of SARS-CoV-2 infection. Male and female K18-hACE2 transgenic mice were infected intranasally with three different doses of SARS-CoV-2. (A) Kaplan-Meier survival curves are presented from pooled data of three independent experiments in panels C, E, and G. (B) Averaged body weight changes are presented for each viral dose of mice in A. (C and D) Data for survival and body weight changes for 11 male and 12 female mice infected with 3.3 × 10⁴ PFU of SARS-CoV-2. Data are stratified for male sex (blue line) and female sex (pink line). (E and F) Data for survival and body weight changes for 11 male and 10 female mice infected with 1.0 × 10⁴ PFU of SARS-CoV-2. Data are stratified for male sex (blue line) and female sex (pink line) (G and H) Data for survival and body weight changes for 15 male and 10 female mice infected with 1.0 × 10³ PFU of SARS-CoV-2. Data are stratified for male sex (blue line) and female sex (pink line). Results represent pooled data from three independent experiments. P values are provided in the figure.