FIG 3.

IFN-λ administration reduced mortality in a mouse model of SARS-CoV-2 infection. Male and female K18-hACE2 transgenic mice were infected with the specified dose of SARS-CoV-2, and survival is displayed as Kaplan-Meier curves. The left panels for each set of infections represent both male and female mice, and the right panels are stratified for male and female mice. (A to C) Data for survival of mice infected with 3.3 × 10⁴ PFU virus (5 male mice, 5 female mice; black closed circle) and mice treated with IFN-λ at the time of infection (5 male, 4 female; green closed circle). (D to F) Data for survival of mice infected with 1.0 × 10⁴ PFU virus (10 male, 9 female; black closed circle) and mice treated with IFN-λ at the time of infection (10 male, 10 female; green closed circle). (G to I) Data for survival of mice infected with 1.0 × 10³ PFU virus (7 male, 10 female; black closed circle) and mice treated with IFN-λ at the time of infection (6 male, 10 female; green closed circle). (J to L) Data for survival of mice infected with 1.0 × 10³ PFU virus (10 male, 10 female; black closed circles) and mice pretreated with IFN-λ for 24 h prior to infection (10 male, 10 female; green open squares). Results represent pooled data from two independent experiments. P values are provided in the figure.