TABLE 3.
Significant enrichment of the Slim Gene Ontology and KEGG pathway for the differential expression gene sets
| DEG comparison | GO term/KEGG pathwaya | FDR P value |
|---|---|---|
| In vivo CSF vs YPD upregulated | Transmembrane transport (GO:0055085) | 8.28E−18 |
| Transport (GO:0006810) | 3.49E−11 | |
| Fatty acid degradation (ec00071_KEGG) | 3.15E−06 | |
| Biological process (GO:0008150) | 2.62E−03 | |
| Valine, leucine, and isoleucine degradation (ec00280_KEGG) | 1.22E−07 | |
| Carbohydrate metabolic process (GO:0005975) | 8.70E−04 | |
| Geraniol degradation (ec00281_KEGG) | 3.15E−03 | |
| α-Linolenic acid metabolism (ec00592_KEGG) | 3.15E−03 | |
| Metabolism of xenobiotics by cytochrome P450 (ec00980_KEGG) | 1.23E−02 | |
| Fatty acid elongation (ec00062_KEGG) | 2.08E−02 | |
| Lysine degradation (ec00310_KEGG) | 2.54E−02 | |
| β-Alanine metabolism (ec00410_KEGG) | 3.76E−02 | |
| In vivo CSF vs YPD downregulated | Lipid metabolic process (GO:0006629) | 8.29E−04 |
| Generation of precursor metabolites and energy (GO:0006091) | 8.98E−04 | |
| Butanoate metabolism (ec00650_KEGG) | 2.96E−02 | |
| hCSF vs rCSF upregulated | Carbohydrate metabolic process (GO:0005975) | 6.68E−11 |
| Citrate cycle (TCA cycle) (ec00020_KEGG) | 4.89E−04 | |
| Carbon fixation in photosynthetic organisms (ec00710_KEGG) | 6.14E−03 | |
| Generation of precursor metabolites and energy (GO:0006091) | 1.59E−02 | |
| Pentose phosphate pathway (ec00030_KEGG) | 9.11E−05 | |
| Glycolysis/gluconeogenesis (ec00010_KEGG) | 1.42E−04 | |
| Biosynthesis of antibiotics (ec01130_KEGG) | 2.28E−03 | |
| Small molecule metabolic process (GO:0044281) | 2.28E−03 | |
| Glutathione metabolism (ec00480_KEGG) | 4.77E−03 | |
| Starch and sucrose metabolism (ec00500_KEGG) | 1.25E−02 | |
| Cofactor metabolic process (GO:0051186) | 1.25E−02 | |
a
GO terms and KEGG pathways with FDR P values of ≤0.05 are listed.