Figure 1.

METTL14 is highly expressed in NSCLC tissues. (A) Expression of m6A regulators in NSCLC and normal tissues (red, upregulated; green, downregulated). The ‘edgeR’ R package was utilized to analyze the differences in gene expression profiles. (B) METTL14 expression in 246 NSCLC tissues and 20 normal tissues in the Gene Expression Omnibus database (dataset accession no. GSE31210). (C) Relative expression levels of METTL14 in patients with stage I, II, III and IV NSCLC based on TCGA database. Data were analyzed using the Kruskal-Wallis test with Steel-Dwass test. (D) Forest plot of the univariate Cox regression analysis. Univariate analysis was performed in m6A-related genes. All bars correspond to the 95% confidence intervals. *P<0.05, **P<0.01 and ***P<0.001. METTL14, methyltransferase-like 14; NSCLC, non-small cell lung cancer; TCGA, The Cancer Genome Atlas.