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. 2021 Oct 21;22(6):847. doi: 10.3892/ol.2021.13108

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Silencing of METTL14 inhibits Twist expression via inactivation of AKT signaling in non-small cell lung cancer cells. (A) Expression levels of epithelial-mesenchymal transition-related proteins (ZEB1, Snail, Slug and Twist) in A549 and SK-MES-1 cells were detected by western blotting following knockdown of METTL14. (B) Levels of p-AKT, AKT, p-GSK3β and GSK3β were evaluated in A549 cells after knockdown of METTL14 **P<0.01 (one-way ANOVA with Tukey's post hoc test). METTL14/ME, methyltransferase-like 14; NC, negative control; p-, phosphorylated; si, small interfering RNA; ZEB1, zinc finger E-box binding homeobox 1.