Table 1. The pRIFLE staging system for AKI 3 .
| Grade of AKI | eCCI | Urine output |
|---|---|---|
| Risk | eCCl decrease by 25% | <0.5 mL/kg/h for 8 h |
| Injury | eCCl decrease by 50% | <0.5 mL/kg/h for 16 h |
| Failure | eCCl decrease by 75% or eCCl < 35 mL/min/1.73 m 2 | <0.3 mL/kg/h for 24 h or anuric for 12 h |
| Loss | Persistent failure > 4 wk | |
| End stage | End-stage renal disease (persistent failure > 3 mo) | |
Abbreviations: AKI, acute kidney injury; eCCl, estimated creatinine clearance; pRIFLE, pediatric risk, injury, failure, loss, and end-stage renal disease.