Table 2. Logistic regression analyses on hepatotoxicity.
| Hepatotoxicity | |||
|---|---|---|---|
| Predictors | Odds ratio | 95% CI | p-value |
| Model 1 (rs6465348: A>G, dominant) | |||
| rs6465348, A/G or G/G (vs. A/A) | 0.08 | (0.004 – 0.58) | 0.03 |
| VCZ AUC (mg×h/L) | 1.02 | (0.997 – 1.05) | 0.08 |
| Model 2 (rs6465348: A>G, recessive) | |||
| rs6465348, G/G (vs. A/A or A/G) | 0.00 | NA* | 0.99 |
| VCZ AUC (mg×h/L) | 1.01 | (0.99 – 1.03) | 0.35 |
| Model 3 (rs2282976: A>G, recessive) | |||
| rs2282976, A/G (vs. A/A) | 3.83 | (0.16 – 43.34) | 0.30 |
| VCZ AUC (mg×h/L) | 0.99 | (0.94 – 1.02) | 0.56 |
VCZ = voriconazole; AUC = area under the curve. *Not estimated because no event observed in G/G group.