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. 2021 Feb 9;59(6):442–446. doi: 10.5414/CP203920

Table 2. Logistic regression analyses on hepatotoxicity.

Hepatotoxicity
Predictors Odds ratio 95% CI p-value
Model 1 (rs6465348: A>G, dominant)
   rs6465348, A/G or G/G (vs. A/A) 0.08 (0.004 – 0.58) 0.03
   VCZ AUC (mg×h/L) 1.02 (0.997 – 1.05) 0.08
Model 2 (rs6465348: A>G, recessive)
   rs6465348, G/G (vs. A/A or A/G) 0.00 NA* 0.99
   VCZ AUC (mg×h/L) 1.01 (0.99 – 1.03) 0.35
Model 3 (rs2282976: A>G, recessive)
   rs2282976, A/G (vs. A/A) 3.83 (0.16 – 43.34) 0.30
   VCZ AUC (mg×h/L) 0.99 (0.94 – 1.02) 0.56

VCZ = voriconazole; AUC = area under the curve. *Not estimated because no event observed in G/G group.