Table 2.
Association of MKI67 with immune cell gene markers in LIHC detected through TIMER
| Immune cell | Gene markers | None | Purity | ||
|---|---|---|---|---|---|
| Cor | P value | Cor | P value | ||
| CD8+ T cell | CD8A | 0.218 | *** | 0.211 | *** |
| CD8B | 0.180 | ** | 0.182 | ** | |
| T cell | CD6 | 0.214 | *** | 0.215 | *** |
| CD3D | 0.279 | *** | 0.278 | *** | |
| CD3E | 0.217 | *** | 0.214 | *** | |
| SH2D1A | 0.195 | ** | 0.194 | ** | |
| TRAT1 | 0.183 | ** | 0.196 | ** | |
| CD3G | 0.279 | *** | 0.274 | *** | |
| CD2 | 0.224 | *** | 0.227 | *** | |
| B cell | CD19 | 0.247 | *** | 0.242 | *** |
| FCRL2 | 0.202 | *** | 0.214 | *** | |
| KIAA0125 | 0.146 | * | 0.146 | * | |
| TNFRSF17 | 0.133 | 0.01 | 0.142 | * | |
| SPIB | 0.376 | *** | 0.357 | *** | |
| PNOC | 0.197 | ** | 0.211 | *** | |
| CD79A | 0.176 | ** | 0.172 | * | |
| Monocyte | CD86 | 0.316 | *** | 0.314 | *** |
| CD115(CSF1R) | 0.184 | ** | 0.190 | ** | |
| TAM | CD68 | 0.272 | *** | 0.263 | *** |
| IL10 | 0.249 | *** | 0.240 | *** | |
| M1 Macrophage | IRF5 | 0.412 | *** | 0.411 | *** |
| COX2(PTGS2) | 0.138 | * | 0.151 | * | |
| M2 Macrophage | CD163 | 0.106 | 0.041 | 0.109 | 0.042 |
| MS4A4A | 0.119 | 0.022 | 0.128 | 0.017 | |
| Neutrophils | FPR1 | 0.239 | *** | 0.244 | *** |
| SIGLEC5 | 0.296 | *** | 0.304 | *** | |
| CSF3R | 0.307 | *** | 0.302 | *** | |
| FCGR3B | 0.158 | * | 0.153 | * | |
| CEACAM3 | 0.120 | 0.021 | 0.136 | 0.017 | |
| CD116(ITGAM) | 0.296 | *** | 0.312 | *** | |
| Natural killer cell | XCL2 | 0.210 | *** | 0.226 | *** |
| KIR2DL1 | − 0.003 | 0.955 | − 0.023 | 0.668 | |
| KIR2DL3 | 0.177 | ** | 0.189 | ** | |
| KIR2DL4 | 0.177 | ** | 0.167 | * | |
| Dendritic cell | CCL13 | 0.181 | ** | 0.162 | * |
| CD209 | 0.171 | ** | 0.180 | ** | |
| HSD11B1 | − 0.352 | *** | − 0.344 | *** | |
| HLA-DPB1 | 0.185 | ** | 0.185 | ** | |
| HLA-DQB1 | 0.148 | * | 0.148 | * | |
| HLA-DRA | 0.196 | ** | 0.199 | ** | |
| HLA-DPA1 | 0.176 | ** | 0.186 | ** | |
| BCDA-1(CD1C) | 0.136 | * | 0.141 | * | |
| BDCA-4(NRP1) | 0.291 | *** | 0.296 | *** | |
| CD11c(ITGAX) | 0.363 | *** | 0.354 | *** | |
| Mast cell | TPSB2 | − 0.028 | 0.595 | − 0.044 | 0.413 |
| HDC | − 0.166 | * | − 0.175 | * | |
| Th1 | IFN-γ(IFNG) | 0.269 | *** | 0.282 | *** |
| TNF-α(TNF) | 0.288 | *** | 0.299 | *** | |
| STAT4 | 0.259 | *** | 0.263 | *** | |
| STAT1 | 0.379 | *** | 0.379 | *** | |
| Th2 | GATA3 | 0.250 | *** | 0.258 | *** |
| STAT6 | 0.162 | * | 0.157 | * | |
| STAT5A | 0.329 | *** | 0.329 | *** | |
| Tfh | BCL6 | 0.172 | ** | 0.179 | ** |
| IL21 | 0.172 | ** | 0.178 | ** | |
| Th17 | STAT3 | 0.200 | ** | 0.198 | ** |
| IL17A | 0.100 | 0.054 | 0.099 | 0.065 | |
| Effector T cell | CX3CR1 | 0.199 | ** | 0.209 | *** |
| FGFBP2 | − 0.140 | * | − 0.120 | 0.026 | |
| FCGR3A | 0.305 | *** | 0.309 | *** | |
| Effector memory T cell | PD-1 (PDCD1) | 0.344 | *** | 0.332 | *** |
| DUSP4 | 0.324 | *** | 0.330 | *** | |
| Central memory T cell | CCR7 | 0.131 | 0.011 | 0.136 | 0.011 |
| SELL | 0.175 | ** | 0.188 | ** | |
| IL7R | 0.176 | ** | 0.185 | ** | |
| Resident memory T cell | CD69 | 0.176 | ** | 0.174 | * |
| ITGAE | 0.306 | *** | 0.297 | *** | |
| CXCR6 | 0.201 | *** | 0.203 | ** | |
| MYADM | 0.391 | *** | 0.375 | *** | |
| Exhausted T cell | TIM-3 (HAVCR2) | 0.344 | *** | 0.345 | *** |
| TIGIT | 0.325 | *** | 0.333 | *** | |
| LAG3 | 0.306 | *** | 0.295 | *** | |
| CXCL13 | 0.273 | *** | 0.295 | *** | |
| LAYN | 0.227 | *** | 0.243 | *** | |
| Resting Treg T cell | FOXP3 | 0.194 | ** | 0.223 | *** |
| IL2RA | 0.308 | *** | 0.309 | *** | |
| Effector Treg T cell | CTLA4 | 0.354 | *** | 0.353 | *** |
| CCR8 | 0.444 | *** | 0.456 | *** | |
| TNFRSF9 | 0.371 | *** | 0.386 | *** | |
TAM, tumor-associated macrophage; LIHC, Liver hepatocellular carcinoma; Treg, regulatory T cells; Tfh, Follicular helper T cells; Th, T helper cells; Purity, tumor purity-adjusted correlation. None, unadjusted correlation; Cor, ρ-value upon Spearman correlation. Significance levels: * P < 0.05; ** P < 0.01; *** P < 0.001