Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 19;12:746492. doi: 10.3389/fimmu.2021.746492

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Balandrán, Dávila-Velderrain, Sandoval-Cabrera, Zamora-Herrera, Terán-Cerqueda, García-Stivalet, Limón-Flores, Armenta-Castro, Rodríguez-Martínez, Leon-Chavez, Vallejo-Ruiz, Hassane, Pérez-Tapia, Ortiz-Navarrete, Guzman and Pelayo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

CXCL11 characterize the MSC niche in B-ALL. (A) CXCL11 and CXCL12 was hypoxia-tracked by using the image-iT probe and analyzed by FACS and representative CXCL11 and CXCL12 immunofluorescence staining in ALL-MSC spheroids (n = 3). (B) CXCL11 was determined by FACS in HBM-MSC and ALL-MSC spheroids (nHBM-MSC = 3, nALL-MSC = 9). (C) CXCL11 and CD19 immunostaining in BM biopsies. (D) CXCR3, CXCR4, and CXCR7 expression analyzed by FACS in B-ALL cell lines (n = 3) and primary B-ALL cells (n = 6). (E) Expression of CXCR2, CXCR3, CXCR4, and CXCR7 in B-ALL and Healthy BM CD19+CD79+ populations obtained from database GSE132509 analyses. MSC, mesenchymal stromal cell; HBM, healthy bone marrow; B-ALL, B-cell acute lymphoblastic leukemia; CAR, CXCL12-derived abundant reticular; FACS, Fluorescence-activated cell sorting. *P < 0.05; **P < 0.01; ****P < 0.0001. Error bars represent SD.