Table 2.
Tertiles of dietary BCAAs in relation to T2D according to the GRS of nested case-control participants
| GRS | Dietary BCAAs (mg/g protein) | P for trend | P for interaction | ||
|---|---|---|---|---|---|
| T1 | T2 | T3 | |||
| Total BCAAs | 0.023 | ||||
| < 4(n = 424) | 1 | 0.75(0.45–1.26) | 0.93(0.53–1.63) | 0.71 | |
| ≥ 4(n = 444) | 1 | 1.69(1.00–2.84) | 2.40(1.39–4.12) | 0.002 | |
| Isoleucine | 0.024 | ||||
| < 4(n = 424) | 1 | 0.82(0.49–1.39) | 1.00(0.57–1.76) | 0.93 | |
| ≥ 4(n = 444) | 1 | 1.95(1.15–3.29) | 2.55(1.48–4.38) | 0.001 | |
| Leucine | 0.036 | ||||
| < 4(n = 424) | 1 | 0.87(0.52–1.46) | 0.98(0.56–1.72) | 0.91 | |
| ≥ 4(n = 444) | 1 | 1.67(0.99–2.81) | 2.38(1.39–4.10) | 0.002 | |
| Valine | 0.041 | ||||
| < 4(n = 424) | 1 | 0.77(0.47–1.29) | 0.89(0.51–1.56) | 0.62 | |
| ≥ 4(n = 444) | 1 | 1.43(0.85–2.39) | 2.12(1.25–3.62) | 0.005 | |
The multivariate logistic regression was used for estimation of ORs and 95% confidence interval (CI)
BCAAs, branched chain amino acids; GRS, genetic risk score; T2D, type 2 diabetes
Results were adjusted for age, sex, BMI, waist circumference, current drinkers, current smokers, physical activity, diabetes treatment, cardiovascular disease, fruit intakes, poultry intakes, and total energy intakes