Table 3.

Pharmacokinetics of fexofenadine in children

Fexofenadine dose and frequency	Age, years	Number of patients	Mean maximum plasma concentration, ng/mL	Mean area under the plasma concentration curve, ng hour/mL	Drug clearance	References
15 mg BID	Infants < 2	55	130‡	–	15.6 L/h	[16]
30 mg BID	> 2– < 7	80	157‡	–	29.9 L/h	[16]
30 mg, single dose	2–5	50	224*	898	–	[18]
30 mg, single dose	6–12	14	178 ± 22†	1090 ± 125	14.4 ± 2.0 ml/min/kg	[17]
60 mg, single dose	6–12	14	286 ± 34†	1892 ± 129	18.4 ± 2.4 ml/min/kg	[17]

BID, twice daily; QD, once daily

^*24 h post dose

^†2.4 ± 0.2 h post dose

^‡Day 8, 3 h and 3–9 h post dose