Table 7.
Histopathological nephrotoxicity scores of the experimental groups
| Group | Glomerular damage | Tubular damage | Tubulointerstitial inflammatory infiltrate | Total nephrotoxicity score | Average | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G0 | G1 | G2 | G3 | G4 | Average | G0 | G1 | G2 | G3 | G4 | Average | G0 | G1 | G2 | Average | |||
| 1. Control | 7 | 0 | 0 | 0 | 0 | 0.0 | 7 | 0 | 0 | 0 | 0 | 0.0 | 7 | 0 | 0 | 0.0 | 0 | 0.0 |
| 2. PREOG | 7 | 0 | 0 | 0 | 0 | 0.0 | 7 | 0 | 0 | 0 | 0 | 0.0 | 7 | 0 | 0 | 0.0 | 0 | 0.0 |
| 3. CP | 4 | 0 | 1 | 1 | 1 | 0.60* | 3 | 0 | 1 | 1 | 2 | 1.40* | 5 | 0 | 2 | 0.48* | 7 | 0.76* |
| 4. PREOG + CP | 6 | 1 | 0 | 0 | 0 | 0.20# | 6 | 1 | 0 | 0 | 0 | 0.20# | 6 | 1 | 0 | 0.20# | 2 | 0.12# |
Total score of 0–2 represents none/mild nephrotoxicity, 3–6 moderate nephrotoxicity, 7–10 severe nephrotoxicity
G Grade
Each value represents mean ± SEM (n = 7). * (p < 0.05) = significantly different from control. # (p < 0.05) = significantly different from CP (50 mg/kg)