Table 3.

Comparison of Pneumonia Scoring Systems in SARS-CoV-2 CAP

Variable	AUC (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)	IDI (95% CIa)
PSI	0.82 (0.78-0.86)	0.83 (0.55-0.91)	0.66 (0.61-0.92)	0.37 (0.31-0.61)	0.94 (0.90-0.97)
PSI + D-dimer	0.83 (0.79-0.87)	0.83 (0.58-0.90)	0.66 (0.62-0.90)	0.37 (0.32-0.59)	0.94 (0.90-0.97)	0.01 (−0.002 to 0.014)
PSI + procalcitonin	0.83 (0.80-0.87)	0.69 (0.65-0.93)	0.80 (0.59-0.84)	0.46 (0.31-0.52)	0.92 (0.90-0.97)	0.02 (−0.01 to 0.04)
PSI + D-dimer + procalcitonin	0.84 (0.80-0.87)	0.70 (0.63-0.92)	0.80 (0.59-0.88)	0.46 (0.32-0.55)	0.92 (0.90-0.97)	0.03 (0.01-0.04)
CURB-65 score	0.79 (0.75-0.84)	0.83 (0.50-0.89)	0.61 (0.58-0.85)	0.33 (0.29-0.52)	0.94 (0.89-0.96)
CURB-65 score + D-dimer	0.80 (0.76-0.84)	0.85 (0.59-0.90)	0.59 (0.56-0.85)	0.33 (0.29-0.50)	0.94 (0.89-0.97)	0.01 (0.00-0.02)
CURB-65 score + procalcitonin	0.81 (0.76-0.85)	0.73 (0.59-0.85)	0.75 (0.63-0.85)	0.41 (0.32-0.52)	0.92 (0.89-0.95)	0.03 (0.01-0.04)
CURB-65 score + D-dimer + procalcitonin	0.81 (0.77-0.85)	0.74 (0.59-0.87)	0.74 (0.59-0.88)	0.41 (0.33-0.54)	0.93 (0.89-0.96)	0.03 (0.02-0.05)

The 95% CI was calculated from the 2.5 and 97.5 percentiles of the bootstrap distribution. AUC = area under the receiver operating characteristic curve; CAP = community-acquired pneumonia; CURB-65 = Confusion, Urea > 7 mM, Respiratory Rate ≥ 30 breaths/min, BP < 90 mm Hg (Systolic) or < 60 mm Hg (Diastolic), Age ≥ 65 Years; IDI = integrated discrimination improvement; NPV = negative predictive value; PPV = positive predictive value; PSI = Pneumonia Severity Index.

^aAsymptotic 95% CI.