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. 2021 Nov 2;240:1–16. doi: 10.1016/j.trsl.2021.10.007

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig 3 — Infection with SARS-CoV-2 causes significant lung inflammation in hamsters. (A) BAL total cell count and differential shows increased inflammatory cell infiltration with SARS-CoV-2 infection in hamsters. (B) BAL cell differential is dominated by monocytes and macrophages across all timepoints. (C) Representative images from hamster lung tissue demonstrate increased staining for MIF, Cd11b, and myeloperoxidase by immunohistochemistry (IHC) at 4, 7, and 14 dpi with the majority of cellular infiltrate staining positive for MIF and Cd11b at all 3 time points.