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. 2021 Nov 2;240:1–16. doi: 10.1016/j.trsl.2021.10.007

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig 4 — Differential gene expression in hamsters with SARS-CoV-2 infection. Volcano plots of overall differential expression analysis show differences in transcriptome of control and SARS-CoV-2 infected hamsters at 4 dpi (A) and 7 dpi (B). The x-axis corresponds to the log (base 2) of the fold change between infected and control hamsters. The y-axis represents the negative log (base 10) of p-values. Cutoffs for effect size and significance are set at >|2| Log₂ fold change and P < 0.05. (C) Box plots of several of the most differentially expressed genes depicting normalized counts for each experimental endpoint. n >= 6 hamsters and/or group for all panels.