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. 2021 Nov 2;240:1–16. doi: 10.1016/j.trsl.2021.10.007

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig 5 — SARS-CoV-2 induced changes in lipidome of BAL (A), cells (B), and lung (C) of infected hamsters. (A, B, C) Score plots of PCA (a) OPLS-DA (b) analysis show the differences in lipidomes of control and SARS-CoV-2 treated hamsters. (c) S-plot of OPLS-DA analysis shows variable correlation vs variable contribution for the OPLS-DA model. Positive correlation implies accumulation in infected group. (d) The variable importance in projection (VIP) score plots reflect the significance of variables for the OPLS-DA models. The VIP >1 was considered to be a statistically significant difference between the 2 groups. PL molecular species that have highest positive VIP score are listed. n >= 6 hamsters and/or group for all panels.