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. 2021 Jul 24;151(11):3361–3378. doi: 10.1093/jn/nxab265

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© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Scatter plots with fitted regression lines of the associations of calculated vitamin D dose per week with serum 25(OH)D at delivery. Variation in supplemental intake was captured by the verified vitamin D composition for each lot of tablets and individual participant adherence with the intervention. (A) Relation between attained maternal 25(OH)D concentrations at delivery and maternal prenatal supplemental vitamin D intake adjusting for maternal 25(OH)D concentrations at enrollment, modeled as a restricted cubic spline. (B) Relation between attained maternal 25(OH)D concentrations at 6 mo postpartum and maternal postpartum supplemental vitamin D intake adjusting for maternal delivery 25(OH)D concentrations, modeled as a linear function. (C) Relation between neonatal (umbilical cord) 25(OH)D concentrations and maternal prenatal supplemental vitamin D intake adjusting for maternal delivery 25(OH)D concentrations, modeled as a restricted cubic spline. (D) Relation between attained infant 25(OH)D concentrations at 6 mo of age and maternal postpartum supplemental vitamin D intake adjusting for umbilical cord 25(OH)D concentrations, modeled as a linear function. Owing to observed heteroskedasticity, robust SEs were estimated in all regression models for assessment of variation in 25(OH)D in response to vitamin D supplementation (Tables 2–5). 25(OH)D, 25-hydroxyvitamin D.