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. 2021 Jul 24;151(11):3361–3378. doi: 10.1093/jn/nxab265

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© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Response profiles of the vitamin D intake–25(OH)D relation in women at delivery. (A) Participants randomly assigned to placebo prenatally. (B) Participants randomly assigned to receive 4200 IU/wk vitamin D prenatally, (C) Participants randomly assigned to receive 16,800 IU/wk prenatally. (D) Participants randomly assigned to receive 28,000 IU/wk prenatally. A “nonresponse” to vitamin D supplementation was defined as a serum 25(OH)D concentration at delivery <50% of the predicted mean 25(OH)D within each treatment group, based on a linear regression model including enrollment 25(OH)D, calculated vitamin D dose per week, and an interaction term between enrollment 25(OH)D and dose per week as predictor variables. Robust SEs were estimated to account for heteroskedasticity. 25(OH)D, 25-hydroxyvitamin D.