TABLE 3.
Cooperative transactivation potential of HoxA9 and HoxA9 mutants with transcriptionally activated versions of Pbx1 containing or lacking the N-terminal 89 amino acids
| HoxA9 protein | Mean fold activation over background (SD) with designated Pbx partner in transactivation through TGATTTATa
|
||
|---|---|---|---|
| None | VP16-Pbx11–343 | VP16-Pbx189–343 | |
| None | 1 | 1 (0.2) | 2 (1.6) |
| HoxA9 | 1.5 (1) | 55 (15) | 30 (9) |
| HoxA9-WF | 0.5 (1) | 22 (9) | 12 (3) |
| HoxA9-WA | 31 (11) | 5 (2.7) | |
| HoxA9-Atet | 0.8 (1) | 24 (6) | 2 (0.2) |
| HoxA9-Gtet | 49 (7) | 3 (1.7) | |
| HoxA9-N51S | 0.7 (1) | 3 (1.5) | 1 (0.5) |
a
The assay was repeated four times.