Table 3.

Changes in gene expression related to glycolytic and oxidative pathways and fiber type. Genes related to the glycolytic and oxidative metabolic pathways were determined by assessing root ontological terms for DEGs (n = 566) processed using PANTHER. Enrichment of ontological terms was determined by p < 0.05 after Bonferroni correction of Fisher's exact p-values. Fiber contraction speed genes were determined by cross referencing a putative fiber type-specific list of genes (Drexler et al., 2012). Genes that shared both glycolytic and β-oxidative ontologies were removed from the analysis. The results show that Crym tg muscle exhibit changes in gene expression consistent with a shift to a slower contractile, more oxidative state.

Glycolytic Pathway Genes		Oxidative Pathway Genes		Fast Contractile Genes		Slow Contractile Genes
# increased	# decreased	# increased	# decreased	# increased	# decreased	# increased	# decreased
5	11	29	20	10	43	54	8