Table 5.
Proteins differentially expressed in Crym tg mice compared to controls by LC.MS/MS associated with muscle twitch speed. A total of 26 of the 85 differentially expressed proteins identified via LC.MS/MS proteomics are associated with fast or slow twitch speeds. The fourth column from the left lists the fiber types these proteins are normally associated with. The fifth column indicates the nature of the shift we observed in the Crym tg. The results show changes indicating changes in proteins associated with both slow and fast twitch fibers.
| Gene | Abundance Ratio: (Crym tg)/(Control) | padj | Type of Gene | Shifted Towards |
|---|---|---|---|---|
| Ptgr2 | 0.001 | 5.06E-16 | slow | fast |
| Bdh1 | 0.314 | 5.06E-16 | slow | fast |
| Rab14 | 0.352 | 5.06E-16 | slow | fast |
| Ankrd2 | 0.388 | 3.09E-12 | slow | fast |
| Paics | 0.427 | 1.69E-07 | fast | slow |
| Csrp3 | 0.435 | 5.06E-16 | slow | fast |
| Tmem65 | 0.563 | 5.03E-04 | slow | fast |
| Cryab | 0.576 | 3.48E-07 | slow | fast |
| Dnaja4 | 0.605 | 2.78E-03 | slow | fast |
| Gbe1 | 0.639 | 1.10E-04 | slow | fast |
| Fhl1 | 0.672 | 1.10E-03 | slow | fast |
| Palmd | 0.676 | 1.36E-03 | slow | fast |
| Sdhc | 0.705 | 6.11E-03 | slow | fast |
| Hspb6 | 0.711 | 8.19E-03 | slow | fast |
| Hspb1 | 0.732 | 1.96E-02 | slow | fast |
| Pfn1 | 0.747 | 3.07E-02 | slow | fast |
| Gstm2 | 1.351 | 1.08E-02 | fast | fast |
| Casq2 | 1.363 | 8.62E-03 | slow | slow |
| Myh7b | 1.381 | 5.68E-03 | slow | slow |
| Idh2 | 1.389 | 4.59E-03 | slow | slow |
| Selenbp2 | 1.403 | 3.13E-03 | slow | slow |
| Kera | 1.445 | 1.12E-03 | fast | fast |
| Fbp2 | 1.724 | 9.86E-08 | fast | fast |
| Myl2 | 2.672 | 5.06E-16 | slow | slow |
| Gpt | 1000 | 5.06E-16 | slow | slow |
| Lta4h | 1000 | 5.06E-16 | fast | fast |