Additional Table 6.
Differences in inflammatory, cardiac and coagulation biomarkers between the groups on admission
| Reference range | Non-ICU | ICU | P-value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Decreased | Normal | Increased | Total | Decreased | Normal | Increased | Total | |||
| CRP (mg/L) | 0-5 | NA | 3.02 (3.02-3.14) 1378/3610 (38.2) |
24.30 (11.40-55.75) 2232/3610 (61.8) 4.86 (fold) |
10.20 (3.14-34.0) 3610/3800 (95.0) |
NA | 3.02 (3.02-3.02) 17/190 (8.9) |
81.50 (37.00-139.00) 173/190 (91.1) 16.3 (fold) |
79.0 (30.05-138.0) 79.0 (30.05-138.0) |
0.00 |
| D-Dimer (μg/L) | 80–583 | 45.77 (32.99-64.93) 20/1651 (1.2) 0.57 (fold) |
341.06 (241.0-444.0) 862/1651 (52.2) |
993.5 (739.2-1665.0) 769/1651 (46.6) 1.70 (fold) |
541.8 (320.0-954.0) 1651/1710 (96.5) |
NA | 371.0 (353.0-408.0) 5/59 (8.5) |
1640.0 (1082.0-4495.2) 54/59 ( 91.5) 2.81 (fold) |
1365.0 (989.1-3982.0) 59/1710 (3.5) |
0.00 |
| Ferritin (mL/ng) | Male 22-322 |
14.70 (10.70-19.30) 97/2705 (3.6) 0.67 (fold) |
130.10 (79.2-213.4) 1631/2705 (60.3) |
541.7 (410.7-776.0) 977/2705 (36.1) 1.68 (fold) |
220.9 (101.5-434.3) 2705/2806 (96.4) |
10.10 (4.22-16.30) 3/101 (3.0) 0.46 (fold) |
188.9 (135.7-242.2) 25/101 (24.8) |
855.3 (540.3-1160.6) 73/101 (72.3) 2.67 (fold) |
570.6 (294.6-1050.9) 101/2806 (3.6) |
0.00 |
| Female 10-291 |
6.75 (5.10-8.30) 82/1311 (6.3) 0.67 (fold) |
81.10 (33.60-150.50) 1039/1311 (79.3) |
454.05 (349.50-654.0) 190/1311 (14.5) 1.56 (fold) |
90.50 (32.0-197.2) 1311/1372 (95.6) |
NA | 117.90 (38.4-171.0) 35/61 (57.4) |
529.85 (441.9-706.9) 26/61 (42.6) 1.82 (fold) |
207.9 (105.4-463.8) 61/1372 (4.4) |
0.00 | |
| Fibrinogen (mg/dL) | 180–450 | 160.66 (134.71-172.56) 24/2260 (1.1) 0.89 (fold) |
321.10 (290.70-357.52) 2039/2260 (90.2) |
486.28 (472.56-501.36) 197/2260 (8.7) 1.08 (fold) |
327.8 (293.7-370.35) 2263/2369 (95.4) |
137.6 (137.6-137.6) 1/109 (0.9) 0.76 (fold) |
353.5 (317.9-379.1) 98/109 (89.9) |
480.0 (466.15-493.64) 10/109 (9.2) 1.07 (fold) |
359.7 (321.1-392.5) 109/2369 (4.6) |
0.00 |
| INR | 0.6-1.2 | NA | 1.08 (1.04-1.13) 1161/1426 (81.4) |
1.31 (1.25-1.46) 265/1426 (18.6) 1.09 (fold) |
1.10 (1.04-1.17) 1426/1561 (91.4) |
NA | 1.12 (1.08-1.17) 68/135 (50.4) |
1.38 (1.26-1.66) 67/135 (49.6) 1.15 (fold) |
1.20 (1.12-1.38) 135/1561 (8.6) |
0.00 |
| PT (second) | 10.1-15.9 | 9.70 (9.40-10.0) 2/1426 (0.1) 0.96 (fold) |
13.00 (12.4-13.7) 1311/1426 (91.9) |
17.8 (16.6-21.6) 113/1426 (7.9) 1.12 (fold) |
13.1 (12.5-13.9) 1426/1561 (91.4) |
NA | 13.90 (13.00-14.70) 100/135 (74.1) |
18.9 (17.10-22.40) 35/135 (25.9) 1.19 (fold) |
14.3 (13.2-16.0) 135/1561 (8.6) |
0.00 |
| Procalcitonin (ng/mL) | < 0.15 | NA | 0.12 (0.12-0.12) 1832/2337 (78.4) |
0.35 (0.20-12.00) 505/2337 (21.6) 2.33 (fold) |
0.12 (0.12-0.12) | NA | 0.12 (0.12-0.12) 29/105 (27.6) |
1.5 (0.32-14.00) 76/105 (72.4) 10 (fold) |
0.39 (0.13-6.5) | 0.00 |
| ESR (mm/hour) | 0-20 | NA | 10.00 (4.00-15.00) 941/1846 (51.0) |
41.0 (31.0-60.0) 905/1846 (49.0) 2.05 (fold) |
20.0 (10.0-41.0) 1846/1944 (95.0) |
NA | 9.50 (4.00-14.00) 26/98 (26.5) |
58.00 (39.00-78.50) 72/98 (73.5) 2.9 (fold) |
45.5 (18.0-68.0) 98/1944 (5.0) |
0.00 |
| Troponin I (ng/L) | 10-23 | 1.0 (1.0-1.0) 1/2102 (0.0) 0.1 (fold) |
10.0 (10.0-10.0) 2020/2102 (96.1) |
54.5 (41.5-130.0) 81/2102 (3.9) 2.37 (fold) |
10.0 (10.0-10.0) 2102/2212 (95.0) |
NA | 10.0 (10.0-10.0) 73/110 (66.4) |
135.0 (54.0-360.0) 37/110 (33.6) 5.87 (fold) |
10.0 (10.0-51.0) 110/2212 (5.0) |
0.00 |
| aPTT (second) | 22-45 | 20.10 (14.90-20.90) 8/1357 (0.6) 0.91 (fold) |
32.8 (29.5-36.5) 1201/1357 (88.5) |
52.75 (48.5-59.0) 148/1357 (10.9) 1.17 (fold) |
33.4 (29.9-38.4) 1357/1475 (92.0) |
12.0 (12.0-12.0) 2/118 (1.7) 0.54 (fold) |
33.3 (29.2-37.3) 103/118 (87.3) |
51.7 (47.8-56.6) 13/118 (11.0) 1.15 (fold) |
34.5 (29.4-40.2) 118/1475 (8.0) |
0.88 |
| LCR | - | NA | NA | NA | 0.13 (0.04-0.36) | NA | NA | NA | 0.02 (0.01-0.04) | 0.00 |
| SII | NA | NA | NA | 547.0 (316.0-1161.3) | NA | NA | NA | 609.0 (336.1-1428.7) | 0.10 | |
Note: Data are expressed as median (interquartile range), number (percentage) and fold to reference range, and were anazluezed by Mann-Whitney U test. aPTT: activated partial prothrombin time; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; INR: international normalized ratio; IQR: interquartile range; LCR: lymphocyte to C-reactive protein ratio; NA: not applicable; PT: prothrombin time; SII: systemic immune-inflammation index.