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Illustration of major fusion proteins developed for cytokine delivery. The three-dimensional protein illustrations were generated in Qutemol[90] based on the Protein Data Bank structures of interleukin-2 (1M47), immunoglobin-G (1IGT), diabody scFv T84.66 (1MOE), scFv based on diabody structure (5GRV), human IgG1-Fc domain (5JII), diphtheria toxin (1F0L), prostatic acid phosphatase (1CVI), human serum albumin (1A06), and fibromodulin (5MX0).
